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Clinical Diabetes 19:71-72, 2001
© American Diabetes Association ®, Inc., 2001

Landmark Study

The Irrefutable Importance of Glycemic Control

Yasser Ousman, MD and Meeta Sharma, MD


   STUDY
 
Stratton IM, Adler AI, Andrew H, Neil W, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR (on behalf of the U.K. Prospective Diabetes Study Group): Association of glycemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321:405–412, 2000


   SUMMARY
 
Objective. To determine the relationship between exposure to glycemia over time and the risk of macrovascular and microvascular complications in patients with type 2 diabetes.

Design. A prospective observational study.

Subjects. A total of 4,585 white, Asian Indian, and Afro-Caribbean United Kingdom Prospective Diabetes Study (UKPDS) patients, whether randomized or not to treatment, were included in analyses of incidence. Of these, 3,642 were included in the analysis of relative risk.

Outcomes measured. Primary predefined aggregate clinical outcomes: any end point or death related to diabetes and all-cause mortality. Secondary aggregate outcomes: myocardial infarction (MI), cerebrovascular accident, amputation, and microvascular disease. Single end points: nonfatal heart failure and cataract extraction. Risk reduction was associated with a 1% reduction in updated mean HbA1c, adjusted for possible confounders at diagnosis of diabetes.

Results. The incidence of clinical complications was significantly associated with glycemia. Each 1% reduction in updated . . . [Full Text of this Article]


   COMMENTARY
 

   Footnotes
 

   REFERENCES
 

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Copyright © 2001 by the American Diabetes Association.