Clinical Diabetes 20:87-88, 2002
© American Diabetes Association ®, Inc., 2002
Extolling the Virtues of Euglycemia
Reviewed by Meeta Sharma, MD
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STUDY
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van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in critically ill patients.
N Engl J Med 345:1359–1367, 2001[Abstract/Free Full Text]
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SUMMARY
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Design. A prospective, randomized, controlled trial, involving adults receiving mechanical ventilation who were admitted to the surgical intensive care unit.
Methods. On admission, patients were randomly assigned to receive intensive insulin therapy (maintenance of blood glucose between 80 and 110 mg/dl) or conventional treatment (infusion of insulin only if blood glucose exceeded 215 mg/dl and maintenance of glucose between 180 and 200 mg/dl). In the intensive treatment group, the insulin drip dose was adjusted according to a strict algorithm by a team of intensive care nurses assisted by a study physician who was not involved in the clinical care of the patients.
Subjects. By the end of a 1-year enrollment period, 1,548 patients were included in the study. All were adults receiving mechanical ventilation and admitted to the surgical intensive care unit. Patients with do-not-resuscitate orders were excluded from the study. Thirteen percent of the subjects had a history of diabetes, and 5% were receiving treatment with insulin. On admission, 75% had blood . . . [Full Text of this Article]
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COMMENTARY
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Footnotes
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REFERENCES
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Copyright © 2002 by the American Diabetes Association.
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