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The Steno Diabetes Study

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	STUDY

 
Gaude P, Vedel P, Larsen N, Jensen GVH, Parving H, Pedersen O: Multifactorial interventions and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 348:383–393, 2003[Abstract/Free Full Text]

	SUMMARY

 
Objective. A comparison of the effect of a targeted, intensified, multifactorial intervention with that of conventional treatment on risk factors for cardiovascular disease (CVD).

Design. Randomized, open, parallel trial at the Steno Diabetes Center in Denmark.

Participants. Eighty patients with type 2 diabetes and microalbuminuria were assigned to receive conventional treatment in accordance with national guidelines, and another 80 were assigned to receive intensive treatment with stepwise implementation of behavior modification and pharmacological therapy that treated hyperglycemia, hypertension, dyslipidemia, and microalbuminuria, along with aspirin.

Primary endpoints. Death from CVD, nonfatal myocardial infarction (MI), nonfatal stroke, revascularization, and amputation.

Results. At a mean follow-up of 7.8 years, patients receiving the intensive therapy had a 53% (95% CI: 27–76%) . . . [Full Text of this Article]

	COMMENTARY

 

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