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Psychosocial Risk Factors for Acute Myocardial Infarction

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	STUDY

 
Rosengren A, Hawken S, Ounpuru S, Sliwa K, Zubaid M, Almahmeed WA, Blackett KN, Sitthi-amorn C, Sato H, Yusuf S, for the INTERHEART investigators: Association of psyhcosocial risk factors with risk of acute myocardial infarction in 11,119 cases and 13, 648 controls from 52 countries (the INTERHEART Study): case-control study. Lancet 364:953 -962, 2004[Medline]

	SUMMARY

 
Objective. To investigate the relation of psychosocial factors to the risk of myocardial infarction (MI).

Design. A case-control study including 11,119 patients with a first MI and 13,648 age- and sex-matched control subjects.

Setting. Two hundred and sixty-two centers in Asia, Europe, the Middle East, Africa, Australia, and North and South America.

Exposure. Psychosocial stress was assessed by four simple questions about stress at work and at home, financial stress, and major life events in the past year. Additional questions assessed locus of control and presence of depression.

End points. Adjusted odds ratios for association with first MI.

Results. Controlled for confounders, people with MI reported . . . [Full Text of this Article]

	COMMENTARY

 

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