Painful Diabetic Neuropathy: A Management-Centered Review



Painful diabetic neuropathy is a common complication of diabetes and can affect many aspects of life and severely limit patients' daily functions. This article reviews the diagnosis, prevention, and management of painful diabetic neuropathy. This condition can be difficult to treat, which frustrates both providers and patients. Commonly used agents, including the recently approved duloxetine and pregabalin, are reviewed, and their effective dose ranges, titration schemes, contraindications, and recommended monitoring are discussed.


  • Mary Margaret Huizinga, MD, is a Department of Veterans Affairs Quality Scholars Fellow at the VA Tennessee Valley Health Services and a clinical fellow in General Internal Medicine at Vanderbilt University Medical Center in Nashville, Tenn. Amanda Peltier, MD, MSCI, is an assistant professor in the Division of Neurology at Vanderbilt University.

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