Emerging Science, Concepts, and Approach to Precision Medicine

Emerging Science, Concepts, and Approach to Precision Medicine

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Macronutrient Intake–Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial
Yoriko Heianza, Wenjie Ma, Tao Huang, Tiange Wang, Yan Zheng, Steven R. Smith, George A. Bray, Frank M. Sacks, Lu Qi

Diabetes Care Nov 2016, 39 (11) 1909-1914; DOI: 10.2337/dc16-1111
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Toward Precision Medicine: TBC1D4 Disruption Is Common Among the Inuit and Leads to Underdiagnosis of Type 2 Diabetes
Despoina Manousaki, Jack W. Kent, Karin Haack, Sirui Zhou, Pingxing Xie, Celia M. Greenwood, Paul Brassard, Deborah E. Newman, Shelley Cole, Jason G. Umans, Guy Rouleau, Anthony G. Comuzzie, J. Brent Richards

Diabetes Care Nov 2016, 39 (11) 1889-1895; DOI: 10.2337/dc16-0769
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Effect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study
Tanja Dujic, Kaixin Zhou, Roger Tavendale, Colin N.A. Palmer, Ewan R. Pearson

Diabetes Care Nov 2016, 39 (11) 1896-1901; DOI: 10.2337/dc16-0706
Open Access
Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes
Maggie Shepherd, Beverley Shields, Suzanne Hammersley, Michelle Hudson, Timothy J. McDonald, Kevin Colclough, Richard A. Oram, Bridget Knight, Christopher Hyde, Julian Cox, Katherine Mallam, Christopher Moudiotis, Rebecca Smith, Barbara Fraser, Simon Robertson, Stephen Greene, Sian Ellard, Ewan R. Pearson, Andrew T. Hattersley

Diabetes Care Nov 2016, 39 (11) 1879-1888; DOI: 10.2337/dc16-0645
Open Access
Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial
Hetal S. Shah, He Gao, Mario Luca Morieri, Jan Skupien, Skylar Marvel, Guillaume Paré, Gaia C. Mannino, Patinut Buranasupkajorn, Christine Mendonca, Timothy Hastings, Santica M. Marcovina, Ronald J. Sigal, Hertzel C. Gerstein, Michael J. Wagner, Alison A. Motsinger-Reif, John B. Buse, Peter Kraft, Josyf C. Mychaleckyj, Alessandro Doria

Diabetes Care Nov 2016, 39 (11) 1915-1924; DOI: 10.2337/dc16-0285
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CYP2C8 and SLCO1B1 Variants and Therapeutic Response to Thiazolidinediones in Patients With Type 2 Diabetes
Adem Y. Dawed, Louise Donnelly, Roger Tavendale, Fiona Carr, Graham Leese, Colin N.A. Palmer, Ewan R. Pearson, Kaixin Zhou

Diabetes Care Nov 2016, 39 (11) 1902-1908; DOI: 10.2337/dc15-2464
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Precision Medicine, Diabetes, and the U.S. Food and Drug Administration
Robert J. Meyer

Diabetes Care Nov 2016, 39 (11) 1874-1878; DOI: 10.2337/dc16-1762
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Precision Medicine, Genomics, and Public Health
Donna K. Arnett, Steven A. Claas

Diabetes Care Nov 2016, 39 (11) 1870-1873; DOI: 10.2337/dc16-1763
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The Application of Genomics in Diabetes: Barriers to Discovery and Implementation
James S. Floyd, Bruce M. Psaty

Diabetes Care Nov 2016, 39 (11) 1858-1869; DOI: 10.2337/dc16-0738
Open Access
The Impact of Precision Medicine in Diabetes: A Multidimensional Perspective
Stephen S. Rich, William T. Cefalu

Diabetes Care Nov 2016, 39 (11) 1854-1857; DOI: 10.2337/dc16-1833

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