Genetics-Type 2 Diabetes

Genetics-Type 2 Diabetes

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A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function
Francesco Casanova, Andrew R. Wood, Hanieh Yaghootkar, Robert N. Beaumont, Samuel E. Jones, Kim M. Gooding, Kunihiko Aizawa, W. David Strain, Andrew T. Hattersley, Faisel Khan, Angela C. Shore, Timothy M. Frayling, Jessica Tyrrell

Diabetes May 2020, 69 (5) 1072-1082; DOI: 10.2337/db19-0862
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Type 2 Diabetes Subtype Responsive to ACCORD Intensive Glycemia Treatment
Arshiya Mariam, Galen Miller-Atkins, Kevin M. Pantalone, Robert S. Zimmerman, John Barnard, Michael W. Kattan, Hetal Shah, Howard L. McLeod, Alessandro Doria, Michael J. Wagner, John B. Buse, Alison A. Motsinger-Reif, Daniel M. Rotroff

Diabetes Care Apr 2021, dc202700; DOI: 10.2337/dc20-2700
Open Access
Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress
Hossam Montaser, Kashyap A. Patel, Diego Balboa, Hazem Ibrahim, Väinö Lithovius, Anna Näätänen, Vikash Chandra, Korcan Demir, Sezer Acar, Tawfeg Ben-Omran, Kevin Colclough, Jonathan M. Locke, Matthew Wakeling, Maria Lindahl, Andrew T. Hattersley, Jonna Saarimäki-Vire, Timo Otonkoski

Diabetes Apr 2021, 70 (4) 1006-1018; DOI: 10.2337/db20-1174
Open Access
The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium
Shylaja Srinivasan, Ling Chen, Jennifer Todd, Jasmin Divers, Samuel Gidding, Steven Chernausek, Rose A. Gubitosi-Klug, Megan M. Kelsey, Rachana Shah, Mary Helen Black, Lynne E. Wagenknecht, Alisa Manning, Jason Flannick, Giuseppina Imperatore, Josep M. Mercader, Dana Dabelea, Jose C. Florez

Diabetes Apr 2021, 70 (4) 996-1005; DOI: 10.2337/db20-0443
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Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank
Hassan S. Dashti, Céline Vetter, Jacqueline M. Lane, Matt C. Smith, Andrew R. Wood, Michael N. Weedon, Martin K. Rutter, Marta Garaulet, Frank A.J.L. Scheer, Richa Saxena

Diabetes Feb 2020, 69 (2) 259-266; DOI: 10.2337/db19-0606
Open Access
Clinical and Molecular Prevalence of Lipodystrophy in an Unascertained Large Clinical Care Cohort
Claudia Gonzaga-Jauregui, Wenzhen Ge, Jeffrey Staples, Cristopher Van Hout, Ashish Yadav, Ryan Colonie, Joseph B. Leader, H. Lester Kirchner, Michael F. Murray, Jeffrey G. Reid, David J. Carey, John D. Overton, Alan R. Shuldiner, Omri Gottesman, Steve Gao, Jesper Gromada, Aris Baras, Judith Altarejos

Diabetes Feb 2020, 69 (2) 249-258; DOI: 10.2337/db19-0447
Open Access
Homozygous Hypomorphic HNF1A Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes
Shivani Misra, Neelam Hassanali, Amanda J. Bennett, Agata Juszczak, Richard Caswell, Kevin Colclough, Jonathan Valabhji, Sian Ellard, Nicholas S. Oliver, Anna L. Gloyn

Diabetes Care Apr 2020, 43 (4) 909-912; DOI: 10.2337/dc19-1843
Open Access
Polycystic Ovary Syndrome and Risk of Type 2 Diabetes, Coronary Heart Disease, and Stroke
Tiantian Zhu, Jinrui Cui, Mark O. Goodarzi

Diabetes Feb 2021, 70 (2) 627-637; DOI: 10.2337/db20-0800
Open Access
A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas
Josephine H. Li, Lukasz Szczerbinski, Adem Y. Dawed, Varinderpal Kaur, Jennifer N. Todd, Ewan R. Pearson, Jose C. Florez

Diabetes Jan 2021, 70 (1) 293-300; DOI: 10.2337/db20-0530
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Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes
Prapaporn Jungtrakoon, Jun Shirakawa, Patinut Buranasupkajorn, Manoj K. Gupta, Dario F. De Jesus, Marcus G. Pezzolesi, Aussara Panya, Timothy Hastings, Chutima Chanprasert, Christine Mendonca, Rohit N. Kulkarni, Alessandro Doria

Diabetes May 2019, 68 (5) 1084-1093; DOI: 10.2337/db17-0821

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