Genetics-Type 2 Diabetes

Genetics-Type 2 Diabetes

Open Access
Longitudinal Analysis of Serum Cytokine Levels and Gut Microbial Abundance Links IL-17/IL-22 With Clostridia and Insulin Sensitivity in Humans
Xin Zhou, Jethro S. Johnson, Daniel Spakowicz, Wenyu Zhou, Yanjiao Zhou, Erica Sodergren, Michael Snyder, George M. Weinstock

Diabetes Aug 2020, 69 (8) 1833-1842; DOI: 10.2337/db19-0592
Open Access
Homozygous Hypomorphic HNF1A Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes
Shivani Misra, Neelam Hassanali, Amanda J. Bennett, Agata Juszczak, Richard Caswell, Kevin Colclough, Jonathan Valabhji, Sian Ellard, Nicholas S. Oliver, Anna L. Gloyn

Diabetes Care Apr 2020, 43 (4) 909-912; DOI: 10.2337/dc19-1843
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A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function
Francesco Casanova, Andrew R. Wood, Hanieh Yaghootkar, Robert N. Beaumont, Samuel E. Jones, Kim M. Gooding, Kunihiko Aizawa, W. David Strain, Andrew T. Hattersley, Faisel Khan, Angela C. Shore, Timothy M. Frayling, Jessica Tyrrell

Diabetes May 2020, 69 (5) 1072-1082; DOI: 10.2337/db19-0862
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Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes
Prapaporn Jungtrakoon, Jun Shirakawa, Patinut Buranasupkajorn, Manoj K. Gupta, Dario F. De Jesus, Marcus G. Pezzolesi, Aussara Panya, Timothy Hastings, Chutima Chanprasert, Christine Mendonca, Rohit N. Kulkarni, Alessandro Doria

Diabetes May 2019, 68 (5) 1084-1093; DOI: 10.2337/db17-0821
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Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank
Hassan S. Dashti, Céline Vetter, Jacqueline M. Lane, Matt C. Smith, Andrew R. Wood, Michael N. Weedon, Martin K. Rutter, Marta Garaulet, Frank A.J.L. Scheer, Richa Saxena

Diabetes Feb 2020, 69 (2) 259-266; DOI: 10.2337/db19-0606
Open Access
Clinical and Molecular Prevalence of Lipodystrophy in an Unascertained Large Clinical Care Cohort
Claudia Gonzaga-Jauregui, Wenzhen Ge, Jeffrey Staples, Cristopher Van Hout, Ashish Yadav, Ryan Colonie, Joseph B. Leader, H. Lester Kirchner, Michael F. Murray, Jeffrey G. Reid, David J. Carey, John D. Overton, Alan R. Shuldiner, Omri Gottesman, Steve Gao, Jesper Gromada, Aris Baras, Judith Altarejos

Diabetes Feb 2020, 69 (2) 249-258; DOI: 10.2337/db19-0447
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DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes
Connor A. Emdin, Amit V. Khera, Krishna Aragam, Mary Haas, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Alexander Bick, Seyedeh M. Zekavat, Akihiro Nomura, Diego Ardissino, James G. Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J. Bown, Nilesh J. Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan

Diabetes Jan 2019, 68 (1) 226-234; DOI: 10.2337/db18-0857
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Genetic Regulation of Pigment Epithelium-Derived Factor (PEDF): An Exome-Chip Association Analysis in Chinese Subjects With Type 2 Diabetes
Chloe Y.Y. Cheung, Chi-Ho Lee, Clara S. Tang, Aimin Xu, Ka-Wing Au, Carol H.Y. Fong, Kelvin K.K. Ng, Kelvin H.M. Kwok, Wing-Sun Chow, Yu-Cho Woo, Michele M.A. Yuen, JoJo Hai, Kathryn C.B. Tan, Tai-Hing Lam, Hung-Fat Tse, Pak-Chung Sham, Karen S.L. Lam

Diabetes Jan 2019, 68 (1) 198-206; DOI: 10.2337/db18-0500
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A Genome-Wide Association Study Identifies Blood Disorder–Related Variants Influencing Hemoglobin A_1c With Implications for Glycemic Status in U.S. Hispanics/Latinos
Jee-Young Moon, Tin L. Louie, Deepti Jain, Tamar Sofer, Claudia Schurmann, Jennifer E. Below, Chao-Qiang Lai, M. Larissa Aviles-Santa, Gregory A. Talavera, Caren E. Smith, Lauren E. Petty, Erwin P. Bottinger, Yii-Der Ida Chen, Kent D. Taylor, Martha L. Daviglus, Jianwen Cai, Tao Wang, Katherine L. Tucker, José M. Ordovás, Craig L. Hanis, Ruth J.F. Loos, Neil Schneiderman, Jerome I. Rotter, Robert C. Kaplan, Qibin Qi

Diabetes Care Sep 2019, 42 (9) 1784-1791; DOI: 10.2337/dc19-0168
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Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study
Adem Y. Dawed, Kaixin Zhou, Nienke van Leeuwen, Anubha Mahajan, Neil Robertson, Robert Koivula, Petra J.M. Elders, Simone P. Rauh, Angus G. Jones, Reinhard W. Holl, Julia C. Stingl, Paul W. Franks, Mark I. McCarthy, Leen M. ‘t Hart, Ewan R. Pearson

Diabetes Care Jun 2019, 42 (6) 1027-1033; DOI: 10.2337/dc18-2182

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