Immunology

Immunology

Open Access
Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes
Alessandra Petrelli, Mark A. Atkinson, Massimo Pietropaolo, Nick Giannoukakis

Diabetes Feb 2021, 70 (2) 313-322; DOI: 10.2337/dbi20-0026
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Baseline Assessment of Circulating MicroRNAs Near Diagnosis of Type 1 Diabetes Predicts Future Stimulated Insulin Secretion
Isaac Snowhite, Ricardo Pastori, Jay Sosenko, Shari Messinger Cayetano, Alberto Pugliese

Diabetes Feb 2021, 70 (2) 638-651; DOI: 10.2337/db20-0817
Open Access
Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice
Fernanda M.C. Sodré, Samal Bissenova, Ylke Bruggeman, Ronak Tilvawala, Dana P. Cook, Claire Berthault, Santanu Mondal, Aïsha Callebaut, Sylvaine You, Raphael Scharfmann, Roberto Mallone, Paul R. Thompson, Chantal Mathieu, Mijke Buitinga, Lut Overbergh

Diabetes Feb 2021, 70 (2) 516-528; DOI: 10.2337/db20-0421
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TLR9 Deficiency in B Cells Promotes Immune Tolerance via Interleukin-10 in a Type 1 Diabetes Mouse Model
Sha Sha, James A. Pearson, Jian Peng, Youjia Hu, Juan Huang, Yanpeng Xing, Luyao Zhang, Ying Zhu, Hongyu Zhao, F. Susan Wong, Li Chen, Li Wen

Diabetes Feb 2021, 70 (2) 504-515; DOI: 10.2337/db20-0373
Open Access
Multinucleated Giant Cells in Adipose Tissue Are Specialized in Adipocyte Degradation
Julia Braune, Andreas Lindhorst, Janine Fröba, Constance Hobusch, Peter Kovacs, Matthias Blüher, Jens Eilers, Ingo Bechmann, Martin Gericke

Diabetes Feb 2021, 70 (2) 538-548; DOI: 10.2337/db20-0293
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Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8⁺ T Cells in Type 1 Diabetes
Terri C. Thayer, Joanne Davies, James A. Pearson, Stephanie J. Hanna, Li Wen, F. Susan Wong

Diabetes Feb 2021, 70 (2) 529-537; DOI: 10.2337/db19-1050
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NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8⁺ T-Cell Numbers
Andrew P. Trembath, Kelsey L. Krausz, Neekun Sharma, Ivan C. Gerling, Clayton E. Mathews, Mary A. Markiewicz

Diabetes Aug 2020, 69 (8) 1749-1762; DOI: 10.2337/db19-0979
Open Access
Intralymphatic Glutamic Acid Decarboxylase With Vitamin D Supplementation in Recent-Onset Type 1 Diabetes: A Double-Blind, Randomized, Placebo-Controlled Phase IIb Trial
Johnny Ludvigsson, Zdenek Sumnik, Terezie Pelikanova, Lia Nattero Chavez, Elena Lundberg, Itxaso Rica, Maria A. Martínez-Brocca, Marisol Ruiz de Adana, Jeanette Wahlberg, Anastasia Katsarou, Ragnar Hanas, Cristina Hernandez, Maria Clemente León, Ana Gómez-Gila, Marcus Lind, Marta Ferrer Lozano, Theo Sas, Ulf Samuelsson, Stepanka Pruhova, Fabricia Dietrich, Sara Puente Marin, Anders Nordlund, Ulf Hannelius, Rosaura Casas

Diabetes Care Jul 2021, 44 (7) 1604-1612; DOI: 10.2337/dc21-0318
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Microencapsulated G3C Hybridoma Cell Graft Delays the Onset of Spontaneous Diabetes in NOD Mice by an Expansion of Gitr⁺ Treg Cells
Luigi Cari, Pia Montanucci, Giuseppe Basta, Maria G. Petrillo, Erika Ricci, Teresa Pescara, Alessia Greco, Sabrina Cipriani, Jun Shimizu, Graziella Migliorati, Giuseppe Nocentini, Riccardo Calafiore, Carlo Riccardi

Diabetes May 2020, 69 (5) 965-980; DOI: 10.2337/db19-0087
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Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size
James J. Ross, Clive H. Wasserfall, Rhonda Bacher, Daniel J. Perry, Kieran McGrail, Amanda L. Posgai, Xiaoru Dong, Andrew Muir, Xia Li, Martha Campbell-Thompson, Todd M. Brusko, Desmond A. Schatz, Michael J. Haller, Mark A. Atkinson

Diabetes Apr 2021, 70 (4) 944-954; DOI: 10.2337/db20-0995

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