Insulin Action-Signal Transduction, Insulin, and Other Hormones

Insulin Action-Signal Transduction, Insulin, and Other Hormones

Open Access
Glucose-Stimulated Insulin Secretion Fundamentally Requires H₂O₂ Signaling by NADPH Oxidase 4
Lydie Plecitá-Hlavatá, Martin Jabůrek, Blanka Holendová, Jan Tauber, Vojtěch Pavluch, Zuzana Berková, Monika Cahová, Katrin Schröder, Ralf P. Brandes, Detlef Siemen, Petr Ježek

Diabetes Jul 2020, 69 (7) 1341-1354; DOI: 10.2337/db19-1130
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Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2
Adam Ramzy, Ali Asadi, Timothy J. Kieffer

Diabetes Jul 2020, 69 (7) 1451-1462; DOI: 10.2337/db19-0276
Open Access
Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)
Justin M. Gregory, T. Jordan Smith, James C. Slaughter, Holly R. Mason, Curtis C. Hughey, Marta S. Smith, Balamurugan Kandasamy, Siri Atma W. Greeley, Louis H. Philipson, Rochelle N. Naylor, Lisa R. Letourneau, Naji N. Abumrad, Alan D. Cherrington, Daniel J. Moore

Diabetes Aug 2019, 68 (8) 1565-1576; DOI: 10.2337/db19-0324
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Leptin: Less Is More
Shangang Zhao, Christine M. Kusminski, Joel K. Elmquist, Philipp E. Scherer

Diabetes May 2020, 69 (5) 823-829; DOI: 10.2337/dbi19-0018
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Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1
Hui Yan, Wangbao Yang, Fenghua Zhou, Xiaopeng Li, Quan Pan, Zheng Shen, Guichun Han, Annie Newell-Fugate, Yanan Tian, Ravikumar Majeti, Wenshe Liu, Yong Xu, Chaodong Wu, Kimberly Allred, Clinton Allred, Yuxiang Sun, Shaodong Guo

Diabetes Feb 2019, 68 (2) 291-304; DOI: 10.2337/db18-0638
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Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis
Yuxin Wu, Quan Pan, Hui Yan, Kebin Zhang, Xiaoqin Guo, Zihui Xu, Wanbao Yang, Yajuan Qi, Cathy A. Guo, Caitlyn Hornsby, Lin Zhang, Aimin Zhou, Ling Li, Yunmei Chen, Weiping Zhang, Yuxiang Sun, Hongting Zheng, Fred Wondisford, Ling He, Shaodong Guo

Diabetes Nov 2018, 67 (11) 2167-2182; DOI: 10.2337/db18-0674
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Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle
Mutsumi Katayama, Oscar P.B. Wiklander, Tomas Fritz, Kenneth Caidahl, Samir El-Andaloussi, Juleen R. Zierath, Anna Krook

Diabetes Mar 2019, 68 (3) 515-526; DOI: 10.2337/db18-0470
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ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations
Anne-Sofie Graae, Niels Grarup, Rasmus Ribel-Madsen, Sara H. Lystbæk, Trine Boesgaard, Harald Staiger, Andreas Fritsche, Niels Wellner, Karolina Sulek, Mads Kjolby, Marie Balslev Backe, Sabina Chubanava, Clara Prats, Annette K. Serup, Jesper B. Birk, Johanne Dubail, Linn Gillberg, Sara G. Vienberg, Anders Nykjær, Bente Kiens, Jørgen F.P. Wojtaszewski, Steen Larsen, Suneel S. Apte, Hans-Ulrich Häring, Allan Vaag, Björn Zethelius, Oluf Pedersen, Jonas T. Treebak, Torben Hansen, Birgitte Holst

Diabetes Mar 2019, 68 (3) 502-514; DOI: 10.2337/db18-0418
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PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity
Themis Thoudam, Chae-Myeong Ha, Jaechan Leem, Dipanjan Chanda, Jong-Seok Park, Hyo-Jeong Kim, Jae-Han Jeon, Yeon-Kyung Choi, Suthat Liangpunsakul, Yang Hoon Huh, Tae-Hwan Kwon, Keun-Gyu Park, Robert A. Harris, Kyu-Sang Park, Hyun-Woo Rhee, In-Kyu Lee

Diabetes Mar 2019, 68 (3) 571-586; DOI: 10.2337/db18-0363
Open Access
Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture
Domenico Accili

Diabetes Sep 2018, 67 (9) 1701-1709; DOI: 10.2337/dbi18-0025

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