Amylin Replacement With Pramlintide in Type 1 and Type 2 Diabetes: A Physiological Approach to Overcome Barriers With Insulin Therapy
Abstract
In Brief
Many insulin-treated diabetic patients still fail to achieve optimal glycemic control and continue to experience problems with hypoglycemia, weight gain, and postprandial hyperglycemia. Adjunctive therapy with pramlintide, a synthetic analog of the human amylin hormone, facilitates a significant improvement of postprandial and overall glycemic control in patients with either type 1 or type 2 diabetes without an increased risk of hypoglycemia or weight gain.
Footnotes
John B. Buse, MD, PhD, CDE, FACE , is an associate professor, chief of the Division of General Medicine and Clinical Epidemiology, and director of the Diabetes Care Center at the University of North Carolina School of Medicine, in Chapel Hill. Christian Weyer, MD, is medical director, and David G. Maggs, MD, MRCP, is senior medical director at Amylin Pharmaceuticals, Inc., in San Diego, Calif.
Note of disclosure: Dr. Buse sits on an advisory panel for and his research is supported by Amylin Pharmaceuticals, Inc. Dr. Weyer and Dr. Maggs are employees of and stock shareholders in the same company. Amylin Pharmaceuticals, Inc., manufactures the synthetic amylin analog pramlintide.
- American Diabetes Association
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