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Reexamining Misconceptions About β-Blockers in Patients With Diabetes

  1. Janet B. McGill, MD
    Clinical Diabetes 2009 Dec; 27(1): 36-46. https://doi.org/10.2337/diaclin.27.1.36

    Article Figures & Tables

    Figures

    • Figure 1.
      Figure 1.

      Stages in the development of heart failure and recommended therapy by stage. EF, ejection fraction; HF, heart failure; FHx CM, family history of cardiomyopathy; LV, left ventricle; LVH, left ventricular hypertrophy. Reprinted with permission from Ref. 11. © 2005 American Heart Association.ACEI, ACE inhibitor

    • Figure 2.
      Figure 2.

      Algorithm for the treatment of hypertension. BB, β-blocker; DBP, diastolic blood pressure; SBP, systolic blood pressure. Reprinted with permission from Ref. 6. © 2003 American Heart Association. ACEI, ACE inhibitor

    • Figure 3.
      Figure 3.

      A1C at baseline and each maintenance month by treatment in the GEMINI trial, including the modified intention-to-treat population. The change from baseline to maintenance month 5 (primary outcome) was significant (mean difference [SD], 0.13% [0.05%]; 95% CI -0.22 to -0.04%; P = 0.004). Error bars indicate SD from mean. Reprinted with permission from Ref. 26. © 2004 American Medical Association

    • Figure 4.
      Figure 4.

      Effects of placebo or carvedilol CR on 24-hour mean systolic blood pressure and diastolic blood pressure obtained by ambulatory monitoring in hypertensive patients after 6 weeks of treatment. Values shown are ± SE. SBP inferences are based on an ad hoc analysis. *P ≤ 0.001 for dose-related trend tests for change from baseline in mean diastolic and systolic blood pressure for all carvedilol CR doses with placebo. DBP, diastolic blood pressure; SBP, systolic blood pressure. Reprinted with permission from Ref. 66.

    Tables

    • Table 1.

      Clinical Trial and Guideline Basis for Compelling Indications for Individual Drug Classes

      Table 1.
    • Table 2.

      AACE Evidence-Based Recommendations for Management of Hypertension and Concomitant Type 2 Diabetes

      Table 2.
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    December 2009, 27(1)
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    Reexamining Misconceptions About β-Blockers in Patients With Diabetes
    Janet B. McGill
    Clinical Diabetes Dec 2009, 27 (1) 36-46; DOI: 10.2337/diaclin.27.1.36
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