PT  - JOURNAL ARTICLE
AU  - Skyler, Jay S.
TI  - Effects of Glycemic Control on Diabetes Complications and on the Prevention of Diabetes
AID  - 10.2337/diaclin.22.4.162
DP  - 2004 Oct 01
TA  - Clinical Diabetes
PG  - 162--166
VI  - 22
IP  - 4
4099  - http://clinical.diabetesjournals.org/content/22/4/162.short
4100  - http://clinical.diabetesjournals.org/content/22/4/162.full
AB  - IN BRIEF Randomized, controlled clinical trials (RCTs), completed during the past several years or currently underway, are defining the scientific basis of contemporary diabetes care. In terms of glycemic control, landmark RCTs have demonstrated that meticulous glycemic control reduces risk of microvascular and neurological complications of diabetes. Studies in pre-diabetes have shown that early intervention slows progression to diabetes. Ongoing studies are examining the effects of glycemic interventions on macrovascular complications of diabetes, the impact of early treatment on the course of diabetes, and whether there are differences depending on the nature of the intervention used.