PT  - JOURNAL ARTICLE
AU  - Niswender, Kevin
TI  - Early and Aggressive Initiation of Insulin Therapy for Type 2 Diabetes: What Is the Evidence?
AID  - 10.2337/diaclin.27.2.60
DP  - 2009 Apr 01
TA  - Clinical Diabetes
PG  - 60--68
VI  - 27
IP  - 2
4099  - http://clinical.diabetesjournals.org/content/27/2/60.short
4100  - http://clinical.diabetesjournals.org/content/27/2/60.full
AB  - Type 2 diabetes is a progressive disease in which b[beta symbol]-cell function continually declines and eventually fails, ultimately requiring nearly all patients to be placed on insulin therapy. An increasing body of evidence suggests that early intensive glycemic control reduces long-term vascular outcomes and potentially may prolong b[beta symbol]-cell lifespan and function. Herein, evidence in favor of early insulin therapy on disease progression and long-term outcomes will be reviewed and placed into clinical context.