TABLE 1.

Differential Effects of GLP-1 Receptor Agonists

GLP-1 Receptor Agonists
Short-ActingLong-Acting
CompoundsExenatideAlbiglutide
LixisenatideDulaglutide
Exenatide QW
Liraglutide
Half-Life2−5 hours12 hours toseveral days
Effects
 Fasting blood glucoseModest reductionStrong reduction
 Postprandial hyperglycemiaStrong reductionModest reduction
 Fasting insulin secretionModest stimulationStrong stimulation
 Postprandial insulin secretionReductionModest stimulation
 Glucagon secretionReductionReduction
 Gastric emptying rateDecelerationNo effect
 Blood pressureReductionReduction
 Heart rateNo effect orsmall increase(0−2 bpm)Moderate increase (2−5 bpm)
 Body weight reduction1−5 kg2−5 kg
 Induction of nausea20−50%, attenuates slowly (weeks to many months)20−40%, attenuates quickly(∼4–8 weeks)
  • Reprinted from ref. 12 with permission of Macmillan Publishers Ltd.